The Sleep Aid That May Harm the Brain
The second ingredient, diphenhydramine (the same drug found in Benadryl), creates the drowsy effect people rely on.
But it comes with a cost.
Diphenhydramine is an anticholinergic, meaning it blocks acetylcholine—a chemical essential for memory, focus, and cognitive health.
Studies have found that people who use anticholinergic medications long-term face up to a 54% higher risk of developing dementia.
Other side effects include:
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Confusion or brain fog
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Dizziness and falls
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Dry mouth and dehydration
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Urinary retention, especially in older adults
Dr. Melillo warns that while these symptoms may seem minor at first, they can quietly snowball—especially in aging adults.
